Rotigotine, a dopamine receptor agonist, increased BDNF protein levels in the rat cortex and hippocampus

  title={Rotigotine, a dopamine receptor agonist, increased BDNF protein levels in the rat cortex and hippocampus},
  author={Naoki Adachi and Aya Yoshimura and Shuichi Chiba and Shintaro Ogawa and Hiroshi Kunugi},
  journal={Neuroscience Letters},
Brain-derived neurotrophic factor (BDNF) critically controls the fate and function of the neuronal network and has received much attention as a target of many brain diseases. Dopaminergic system dysfunction has also been implicated in a variety of neuropsychiatric diseases. Rotigotine, a non-ergot dopamine receptor agonist, is used in the treatment of Parkinson's disease and restless legs syndrome. To investigate the effects of rotigotine on neuronal functions both in vivo and in vitro, rats… CONTINUE READING


Publications citing this paper.


Publications referenced by this paper.
Showing 1-10 of 42 references

24 H

Y. Katanuma, T. Numakawa, +4 authors T. Inoue
Kunugi, Phencyclidine rapidly decreases neuronal mRNA of brain-derived neurotrophic 25 factor, Synapse 68 • 2014
View 1 Excerpt

Restless legs syndrome: pathophysiology and treatment.

Current treatment options in neurology • 2014
View 1 Excerpt


N. Adachi, T. Numakawa, +4 authors M. Richards
18 Katoh-Semba, H Kunugi. Phencyclidine-induced decrease of synaptic connectivity via 19 inhibition of BDNF secretion in cultured cortical neurons, 23 Cereb. Cortex • 2013
View 2 Excerpts

Similar Papers

Loading similar papers…