Rotenone potentiates dopamine neuron loss in animals exposed to lipopolysaccharide prenatally.

@article{Ling2004RotenonePD,
  title={Rotenone potentiates dopamine neuron loss in animals exposed to lipopolysaccharide prenatally.},
  author={Zaodung Ling and Qin A. Chang and Chong wai Tong and Susan E Leurgans and Jack W Lipton and Paul M. Carvey},
  journal={Experimental neurology},
  year={2004},
  volume={190 2},
  pages={373-83}
}
We previously demonstrated that treating gravid female rats with the bacteriotoxin lipopolysaccharide (LPS) led to the birth of offspring with fewer than normal dopamine (DA) neurons. This DA neuron loss was long-lived and associated with permanent increases in the pro-inflammatory cytokine tumor necrosis factor alpha (TNFalpha). Because of this pro… CONTINUE READING