Rotenone induces apoptosis in MCF-7 human breast cancer cell-mediated ROS through JNK and p38 signaling.

@article{Deng2010RotenoneIA,
  title={Rotenone induces apoptosis in MCF-7 human breast cancer cell-mediated ROS through JNK and p38 signaling.},
  author={Yea-Tzy Deng and Hsiu-Chen Huang and Jen-kun Lin},
  journal={Molecular carcinogenesis},
  year={2010},
  volume={49 2},
  pages={141-51}
}
Rotenone is an inhibitor of the mitochondrial electron transport chain complex I, resulting in the generation of reactive oxygen species (ROS). Rotenone has been shown to display anticancer activity through the induction of apoptosis in various cancer cells. However, the underlying mechanism is still not fully understood. Here, rotenone showed a strong growth inhibitory effect against human breast cancer MCF-7 cells. DNA flow cytometric analysis, chromatin condensation, and poly (ADP-ribose… CONTINUE READING

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