Rotenone-induced apoptosis is mediated by p38 and JNK MAP kinases in human dopaminergic SH-SY5Y cells.

@article{Newhouse2004RotenoneinducedAI,
  title={Rotenone-induced apoptosis is mediated by p38 and JNK MAP kinases in human dopaminergic SH-SY5Y cells.},
  author={Kathleen Newhouse and S. L. Hsuan and Seung Hee Chang and Beibei Cai and Yupeng Wang and Zhengui Xia},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2004},
  volume={79 1},
  pages={
          137-46
        }
}
Rotenone is a naturally derived pesticide that has recently been shown to evoke the behavioral and pathological symptoms of Parkinson's disease in animal models. Though rotenone is known to be an inhibitor of the mitochondrial complex I electron transport chain, little is known about downstream pathways leading to its toxicity. We used human dopaminergic SH-SY5Y cells to study mechanisms of rotenone-induced neuronal cell death. Our results suggest that rotenone, at nanomolar concentrations… CONTINUE READING

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