Rotenone down-regulates HSPA8/hsc70 chaperone protein in vitro: A new possible toxic mechanism contributing to Parkinson's disease.

@article{Sala2016RotenoneDH,
  title={Rotenone down-regulates HSPA8/hsc70 chaperone protein in vitro: A new possible toxic mechanism contributing to Parkinson's disease.},
  author={Gessica Sala and Daniele Marinig and Chiara Riva and Alessandro Arosio and Giovanni Stefanoni and Laura Brighina and Matteo Formenti and Lilia Alberghina and Anna Maria Colangelo and Carlo Ferrarese},
  journal={Neurotoxicology},
  year={2016},
  volume={54},
  pages={161-169}
}
HSPA8/hsc70 (70-kDa heat shock cognate) chaperone protein exerts multiple protective roles. Beside its ability to confer to the cells a generic resistance against several metabolic stresses, it is also involved in at least two critical processes whose activity is essential in preventing Parkinson's disease (PD) pathology. Actually, hsc70 protein acts as the main carrier of chaperone-mediated autophagy (CMA), a selective catabolic pathway for alpha-synuclein, the main pathogenic protein that… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS