Rotenone, Paraquat, and Parkinson’s Disease

  title={Rotenone, Paraquat, and Parkinson’s Disease},
  author={Caroline M. Tanner and Freya Kamel and G. Webster Ross and Jane A. Hoppin and Samuel M. Goldman and Monica Korell and Connie Marras and Grace S. Bhudhikanok and Meike Kasten and Anabel R. Chade and Kathleen Comyns and Marie Barber Richards and Cheryl C Meng and Benjamin Priestley and Hubert Henery Fernandez and Franca Cambi and David M. Umbach and Aaron E. Blair and Dale P Sandler and James William Langston},
  booktitle={Environmental health perspectives},
BACKGROUND Mitochondrial dysfunction and oxidative stress are pathophysiologic mechanisms implicated in experimental models and genetic forms of Parkinson's disease (PD). Certain pesticides may affect these mechanisms, but no pesticide has been definitively associated with PD in humans. OBJECTIVES Our goal was to determine whether pesticides that cause mitochondrial dysfunction or oxidative stress are associated with PD or clinical features of parkinsonism in humans. METHODS We assessed… CONTINUE READING
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