Rotaviruses: from pathogenesis to vaccination.

  title={Rotaviruses: from pathogenesis to vaccination.},
  author={Harry B Greenberg and Mary K. Estes},
  volume={136 6},
Rotaviruses cause life-threatening gastroenteritis in children worldwide; the enormous disease burden has focused efforts to develop vaccines and led to the discovery of novel mechanisms of gastrointestinal virus pathogenesis and host responses to infection. Two live-attenuated vaccines for gastroenteritis (Rotateq [Merck] and Rotarix) have been licensed in many countries. This review summarizes the latest data on these vaccines, their effectiveness, and challenges to global vaccination. Recent… CONTINUE READING
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