Rotavirus virus-like particles administered mucosally induce protective immunity.

@article{ONeal1997RotavirusVP,
  title={Rotavirus virus-like particles administered mucosally induce protective immunity.},
  author={Christine M O'Neal and Sue E. S. Crawford and Mary K. Estes and Margaret E Conner},
  journal={Journal of virology},
  year={1997},
  volume={71 11},
  pages={
          8707-17
        }
}
We have evaluated the immunogenicity and protective efficacy of rotavirus subunit vaccines administered by mucosal routes. Virus-like particles (VLPs) produced by self-assembly of individual rotavirus structural proteins coexpressed by baculovirus recombinants in insect cells were the subunit vaccine tested. We first compared the immunogenicities and protective efficacies of VLPs containing VP2 and VP6 (2/6-VLPs) and G3 2/6/7-VLPs mixed with cholera toxin and administered by oral and intranasal… CONTINUE READING

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