Rotavirus vaccines: current prospects and future challenges

@article{Glass2006RotavirusVC,
  title={Rotavirus vaccines: current prospects and future challenges},
  author={Roger I Glass and Umesh D. Parashar and Joseph S. Bresee and Reina M Turcios and Thea K. Fischer and Marc-Alain Widdowson and Baoming Jiang and Jon R. Gentsch},
  journal={The Lancet},
  year={2006},
  volume={368},
  pages={323-332}
}
Rotavirus vaccines: Opportunities and challenges
TLDR
Rotavirus vaccines remain to be fully evaluated in low-income countries where reduced immunogenicity of oral vaccines, greater strain diversity and difficulties reaching target populations might decrease immunisation programme performance.
Prevention of childhood rotavirus disease through the use of Rotarix™ and RotaTeq™ vaccines
TLDR
More data on the efficacy of these two new vaccines in low-income nations are needed, particularly in Asia and Africa, before global inclusion of rotavirus vaccines into national immunisation programmes can be recommended.
Introduction of rotavirus vaccines in developing countries: remaining challenges
TLDR
Since the majority of childhood deaths from rotavirus occur in the developing countries of Africa and Asia, widespread use of vaccine in these two continents will be necessary before a major impact on global diarrhoea mortality is seen.
Incorporation of a rotavirus vaccine into the national immunisation schedule in the United Kingdom: a review
TLDR
This article provides a review of the product profile of the Rotarix vaccine for use in the national immunisation programme in the UK from an expert perspective and concludes that this single G1P[8] strain-based human rotavirus vaccine has demonstrated high efficacy in preventing severe rotav virus gastroenteritis in the first 3 years of life in middle- and high-income countries.
Assessing the effectiveness and public health impact of rotavirus vaccines after introduction in immunization programs.
TLDR
Data is reviewed for the protective efficacy of the 2 new rotavirus vaccines, with emphasis on issues particularly important for consideration as these vaccines are introduced in routine infant immunization programs.
Rotavirus vaccines in developed countries
TLDR
Large-scale safety and efficacy studies of two new live, oral, attenuated vaccines have shown excellent efficacy against severe rotavirus gastroenteritis, and both studies detected no association with intussusception with these new vaccines when administered at the scheduled ages.
Performance of rotavirus vaccines in developed and developing countries
TLDR
Previous candidate rotavirus vaccines and vaccines in current use are reviewed, with emphasis on their performance in developed versus developing countries, and future efforts for these vaccines should focus on optimizing the efficacy and delivery.
Rotavirus vaccines in routine use.
  • J. Tate, U. Parashar
  • Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2014
TLDR
The risk-benefit analysis of rotavirus vaccines is extremely favorable but other strategies to improve the effectiveness of the vaccine, particularly in lower middle income settings, should be considered.
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