Rotavirus core shell subdomains involved in polymerase encapsidation into virus-like particles.

@article{Boudreaux2013RotavirusCS,
  title={Rotavirus core shell subdomains involved in polymerase encapsidation into virus-like particles.},
  author={Crystal E. Boudreaux and Donald C. Vile and Brian L. Gilmore and Justin R. Tanner and Deborah F. Kelly and Sarah M. McDonald},
  journal={The Journal of general virology},
  year={2013},
  volume={94 Pt 8},
  pages={
          1818-26
        }
}
The triple-layered rotavirus virion encases an 11-segmented, dsRNA genome and 11-12 copies of the viral polymerase (VP1). VP1 transcribes and replicates the genome while tethered beneath the VP2 core shell. Genome replication (i.e. minus-strand RNA synthesis) by VP1 occurs in association with core assembly. During this process, VP2 directly engages VP1, thereby (i) packaging the polymerase into a nascent core and (ii) triggering the enzyme to initiate minus-strand RNA synthesis on bound plus… CONTINUE READING

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