Rotavirus alters paracellular permeability and energy metabolism in Caco-2 cells.

@article{Dickman2000RotavirusAP,
  title={Rotavirus alters paracellular permeability and energy metabolism in Caco-2 cells.},
  author={Kathleen G Dickman and Scott J. Hempson and Joseph A Anderson and Sarah Lipp{\'e} and Lian-san Zhao and Robert B Burakoff and Robert D. Shaw},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2000},
  volume={279 4},
  pages={
          G757-66
        }
}
Rotaviruses infect epithelial cells of the small intestine, but the pathophysiology of the resulting severe diarrhea is incompletely understood. Histological damage to intestinal epithelium is not a consistent feature, and in vitro studies showed that intestinal cells did not undergo rapid death and lysis during viral replication. We show that rotavirus infection of Caco-2 cells caused disruption of tight junctions and loss of transepithelial resistance (TER) in the absence of cell death. TER… CONTINUE READING
Highly Cited
This paper has 74 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 56 citations

74 Citations

0510'01'04'08'12'16
Citations per Year
Semantic Scholar estimates that this publication has 74 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 52 references