Rotavirus alters paracellular permeability and energy metabolism in Caco-2 cells.

  title={Rotavirus alters paracellular permeability and energy metabolism in Caco-2 cells.},
  author={Kathleen G Dickman and Scott J. Hempson and Joseph A Anderson and Sarah Lipp{\'e} and Lian-san Zhao and Robert B Burakoff and Robert D. Shaw},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  volume={279 4},
Rotaviruses infect epithelial cells of the small intestine, but the pathophysiology of the resulting severe diarrhea is incompletely understood. Histological damage to intestinal epithelium is not a consistent feature, and in vitro studies showed that intestinal cells did not undergo rapid death and lysis during viral replication. We show that rotavirus infection of Caco-2 cells caused disruption of tight junctions and loss of transepithelial resistance (TER) in the absence of cell death. TER… CONTINUE READING
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