Rotavirus Vaccine: Current Use and Future Considerations

@article{BruijningVerhagen2017RotavirusVC,
  title={Rotavirus Vaccine: Current Use and Future Considerations},
  author={Patricia Cj Bruijning-Verhagen and Michelle J. Groome},
  journal={The Pediatric Infectious Disease Journal},
  year={2017},
  volume={36},
  pages={676–678}
}
2 Citations
Establishment of a cell-based RT-qPCR assay for detection of multivalent rotavirus vaccine.
TLDR
This one-step TaqMan probe-based quantitative RT-qPCR assay combined with cell-based method is a more rapid, cost-effective and high-throughput way for detecting multivalent rotavirus vaccine, and will be a valuable tool in the quality control and stability monitoring of live multivalent rotate virus vaccine. Expand
Establishment of a cell‐based quantitative reverse transcription‐polymerase chain reaction (RT‐qPCR) assay for detection of multivalent rotavirus vaccine
Because of deficiencies of traditional potency tests in rotavirus detection, a one‐step TaqMan probe‐based quantitative reverse transcription‐polymerase chain reaction (RT‐qPCR) assay combined withExpand

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The data highlight the benefits of vaccination and should provide valuable evidence to sustain vaccine use in developing countries and encourage other countries to adopt routine rotavirus vaccination to reduce the health burden of severe childhood gastroenteritis. Expand
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TLDR
Evaluating updated data and meeting participants agreed with statements from expert bodies that the benefits of vaccination with currently available rotavirus vaccines outweigh the low risk of vaccination-associated intussusception, but further research is needed to better understand the relationship of intussUSception to wild-type rotvirus and rotav virus vaccines. Expand
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