Rotavirus RNA replication and gene expression.

  title={Rotavirus RNA replication and gene expression.},
  author={J. Patton},
  journal={Novartis Foundation symposium},
          64-77; discussion 77-81
  • J. Patton
  • Published 2001
  • Medicine, Biology
  • Novartis Foundation symposium
  • Rotavirus mRNAs are capped but non-polyadenylated and serve as templates for both the synthesis of viral proteins and the segmented dsRNA genome. Viral proteins involved in RNA replication include the RNA polymerase (VP1), the core scaffold protein (VP2) and the non-structural RNA-binding proteins (NSP2 and NSP5). VP2 enhances dsRNA synthesis in vitro, possibly by forming platform structures on which VP1 functions. NSP2 octamers have NTPase and helix-destabilizing activity, and in conjunction… CONTINUE READING
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