Rotavirus Overview

  title={Rotavirus Overview},
  author={David I Bernstein},
  journal={The Pediatric Infectious Disease Journal},
  • D. Bernstein
  • Published 1 March 2009
  • Medicine
  • The Pediatric Infectious Disease Journal
Rotaviral gastroenteritis is a serious public health problem in both developed and developing countries. The disease is ubiquitous, affecting nearly all children by the age of 5 years. It is the most common cause of hospitalizations for gastroenteritis among children in the United States (30%–70% depending on the season) and is associated with direct and indirect costs of approximately $1 billion per year. Symptoms of rotaviral gastroenteritis are nonspecific (ie, diarrhea, vomiting, and fever… 
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Seasonal trending of rotavirus infection in infantile patients from Baghdad with acute gastroenteritis
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Rotavirus infection was decrease significantly in Babylon province after routine introduction of rotavirus vaccination, and the effectiveness of Rota vaccine in modification of severity and prevalence of rotvirus infection among children was evaluated.
Prevalence of severe acute rotavirus gastroenteritis and intussusceptions in Ghanaian children under 5 years of age.
Although the peak age of rotavirus gastroenteritis and intussusceptions overlapped, there was no seasonal correlation between them and the high prevalence of mixed G/P genotypes in Ghanaian children may affect the effectiveness of vaccination.
Prevalence of enteric pathogen-associated community gastroenteritis among kindergarten children in Gaza
A high prevalence of parasitic enteropathogens and a relatively low prevalence of bacterial and viralEnteric pathogen-associated community gastroenteritis among kindergarten children in Gaza city is demonstrated and children aged 3 years old showed the highest prevalence of isolated enteropathogen.
Nosocomial rotavirus infection: An up to date evaluation of European studies
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Clinical Characteristics and Outcome in Norovirus Gastroenteritis
The clinical manifestations on the day after onset of diarrhea, vomiting and fever reflected the occurrence of norovirus infection in children with sporadic gastroenteritis.


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RV detection was greatest when diarrhea, vomiting and fever occurred together and lowest when each symptom occurred alone, suggesting the spectrum of symptoms of rotavirus disease in children at the time of admission to the hospital or short stay unit may be broader than previously recognized.
Rotavirus infection in adults
Hospitalizations and deaths from diarrhea and rotavirus among children <5 years of age in the United States, 1993-2003.
The largest US hospital discharge database available, the Healthcare Cost and Utilization Project (HCUP), is used to study national rates, trends, and risk factors for diarrhea- and rotavirus-associated hospitalizations and deaths among children <5 years of age, to establish a baseline against which vaccine implementation can be measured.
Nonmedical Costs Associated With Rotavirus Disease Requiring Hospitalization
The results from the largest prospective study in the United States determining the nonmedical costs of severe rotavirus infections may exceed $22 million annually are reported, suggesting that the non medical costs associated with mild to moderate rotav virus disease have been similarly underestimated.
Diarrhea- and Rotavirus-Associated Hospitalizations Among Children Less Than 5 Years of Age: United States, 1997 and 2000
An effective rotavirus vaccine will likely reduce substantially the burden of severe rotav virus disease, estimated to account for 4% to 5% of all hospitalizations and ∼30% of hospitalizations for watery diarrhea among children <5 years of age.
Rotavirus vaccines: current prospects and future challenges
Disease burden and risk factors for hospitalizations associated with rotavirus infection among children in New York State, 1989 through 2000
In New York State diarrhea is a common hospital discharge diagnosis and contributes ∼13% of all hospitalizations among children <5 years of age, and when hospitals with maximum recording were used as a reference point, >30% of diarrhea hospitalizations were recorded as likely the result of rotavirus.
A Case-Control Study to Determine Risk Factors for Hospitalization for Rotavirus Gastroenteritis in U.S. Children
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The temporal and geographical distribution of human rotavirus G and P types was reviewed by analysing a total of 45571 strains collected globally from 124 studies reported from 52 countries on five continents published between 1989 and 2004 and revealed several characteristic features.
Use of Active Surveillance to Validate International Classification of Diseases Code Estimates of Rotavirus Hospitalizations in Children
The sensitivity of the rotavirus ICD code among children hospitalized for AGE by using active surveillance forRotavirus at a tertiary children's hospital was evaluated and it was indicated that the numbers of national rotav virus hospitalization discharges may be substantially greater than previously estimated.