Rotational behaviour produced by intranigral injections of bovine and human β-casomorphins in rats

@article{HerreraMarschitz1989RotationalBP,
  title={Rotational behaviour produced by intranigral injections of bovine and human β-casomorphins in rats},
  author={Mario Herrera-Marschitz and Lars Terenius and Lars Grehn and Urban Ungerstedt},
  journal={Psychopharmacology},
  year={1989},
  volume={99},
  pages={357-361}
}
The biological activity of β-casein derived β-casomorphin peptides was evaluated by injecting bovine β-casomorphin-5 (Tyr-Pro-Phe-Pro-Gly), the homologous sequence in human β-casein (Tyr-Pro-Phe-Val-Glu) and the corresponding N-terminal tetrapeptides into the left substantia nigra of rats. Their ability to produce rotational behaviour was compared to that produced by three reference compounds, morphine, d-ala2 d-leu5enkephalin and U50,488H, ligands for μ, δ and κ types of opioid receptors… CONTINUE READING
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