Rotational behaviour in rats with unilateral striatal kainic acid lesions: A behavioural model for studies on intact dopamine receptors

@article{Schwarcz1979RotationalBI,
  title={Rotational behaviour in rats with unilateral striatal kainic acid lesions: A behavioural model for studies on intact dopamine receptors},
  author={Robert M. Schwarcz and Kjell Fuxe and Luigi Francesco Agnati and Tomas Ho¨kfelt and Joseph T Coyle},
  journal={Brain Research},
  year={1979},
  volume={170},
  pages={485-495}
}
Rotational behaviour can be induced in rats with unilateral kainic acid induced degeneration of the neostriatum and adjacent regions by means of dopaminergic drugs. Kainic acid lesioned rats, when challenged with apomorphine or the ergot compounds elymoclavine, lergotrile and bromocriptine, perform dose-related turning towards the lesioned side. Blockade of the rotations by a number of dopamine receptor antagonists indicates dopaminergic involvement. Since kainic acid treatment had previously… CONTINUE READING

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