Rotary spray congealing of a suspension: effect of disk speed and dispersed particle properties.

@article{Mackaplow2006RotarySC,
  title={Rotary spray congealing of a suspension: effect of disk speed and dispersed particle properties.},
  author={Michael B. Mackaplow and Isidro E Zarraga and Jeffrey F. Morris},
  journal={Journal of microencapsulation},
  year={2006},
  volume={23 7},
  pages={793-809}
}
Microspheres were produced by rotary spray congealing molten suspensions composed of poloxamer 188 and a single solid excipient. Six different excipients, spanning a range of particle size, density and morphology were used. The size distribution, true density and shape of the resulting congealed particles were assessed. Disk rotation speed had the most significant effect on microsphere size, with higher speeds yielding smaller congealed particles. At low disk speeds, congealed particle size… CONTINUE READING