Rotamer strain energy in protein helices - quantification of a major force opposing protein folding.

@article{Penel2001RotamerSE,
  title={Rotamer strain energy in protein helices - quantification of a major force opposing protein folding.},
  author={Simon Penel and Andrew J. Doig},
  journal={Journal of molecular biology},
  year={2001},
  volume={305 4},
  pages={961-8}
}
It is widely believed that the dominant force opposing protein folding is the entropic cost of restricting internal rotations. The energetic changes from restricting side-chain torsional motion are more complex than simply a loss of conformational entropy, however. A second force opposing protein folding arises when a side-chain in the folded state is not in its lowest-energy rotamer, giving rotameric strain. chi strain energy results from a dihedral angle being shifted from the most stable… CONTINUE READING

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