Rosuvastatin stimulates clonogenic potential and anti-inflammatory properties of endothelial progenitor cells.

@article{Fadini2010RosuvastatinSC,
  title={Rosuvastatin stimulates clonogenic potential and anti-inflammatory properties of endothelial progenitor cells.},
  author={Gian Paolo Fadini and Mattia Albiero and Elisa Boscaro and Lisa Menegazzo and Anna Cabrelle and Teodoro Piliego and Massimo Federici and Carlo Agostini and Angelo Avogaro},
  journal={Cell biology international},
  year={2010},
  volume={34 7},
  pages={709-15}
}
EPCs (endothelial progenitor cells) exert vasculoprotective effects and can be used for regenerative therapies. However, several isolation protocols have been described, with inconsistent results. Statins are among the most effective compounds that stimulate EPC numbers in vivo and ex vivo. We aim to describe the effects of rosuvastatin on different subtypes of putative EPCs. EPCs were cultured from mononuclear cells of blood donors and isolated according to three protocols: CFU-EC (colony… CONTINUE READING

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