Rosuvastatin reduces atherosclerotic lesions and promotes progenitor cell mobilisation and recruitment in apolipoprotein E knockout mice.

@article{Schroeter2009RosuvastatinRA,
  title={Rosuvastatin reduces atherosclerotic lesions and promotes progenitor cell mobilisation and recruitment in apolipoprotein E knockout mice.},
  author={Marco R Schroeter and Tim Humboldt and Katrin Sch{\"a}fer and Stavros V. Konstantinides},
  journal={Atherosclerosis},
  year={2009},
  volume={205 1},
  pages={63-73}
}
Statins enhance incorporation of bone marrow-derived cells into experimental neointimal lesions. However, the contribution of progenitor cells to progression of spontaneous atherosclerotic plaques, and the possible modulatory role of statins in this process, remain poorly understood. We compared the effects of rosuvastatin (1 and 10mg/kg BW) and pravastatin (10mg/kg) on progenitor cell mobilisation, recruitment into atherosclerotic plaques, and lesion growth. Statins were administered over 8… CONTINUE READING

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