Rosuvastatin pharmacokinetics and pharmacogenetics in Caucasian and Asian subjects residing in the United States

@article{Birmingham2014RosuvastatinPA,
  title={Rosuvastatin pharmacokinetics and pharmacogenetics in Caucasian and Asian subjects residing in the United States},
  author={Bruce K. Birmingham and Sarah R. Bujac and Robert Elsby and Connie T. Azumaya and Julie A. Zalikowski and Yusong Chen and Kenneth Eunhan Kim and Helen J. Ambrose},
  journal={European Journal of Clinical Pharmacology},
  year={2014},
  volume={71},
  pages={329-340}
}
Systemic exposure to rosuvastatin in Asian subjects living in Japan or Singapore is approximately twice that observed in Caucasian subjects in Western countries or in Singapore. This study was conducted to determine whether pharmacokinetic differences exist among the most populous Asian subgroups and Caucasian subjects in the USA. Rosuvastatin pharmacokinetics was studied in Chinese, Filipino, Asian-Indian, Korean, Vietnamese, Japanese and Caucasian subjects residing in California. Plasma… CONTINUE READING

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Phase I study of ZD4522 (rosuvastatin), a new HMG-CoA reductase inhibitor—evaluation of tolerance and pharmacokinetics in healthy adult male volunteers after single and repeated oral administration

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