Rosuvastatin calcium in acute coronary syndromes

@article{Aggarwal2013RosuvastatinCI,
  title={Rosuvastatin calcium in acute coronary syndromes},
  author={R. Aggarwal and R. Showkathali},
  journal={Expert Opinion on Pharmacotherapy},
  year={2013},
  volume={14},
  pages={1215 - 1227}
}
Introduction: Low-density lipoprotein cholesterol (LDL-C) reduction using 3-hydroxy-3-methyl glutaryl coenzyme A (HMGCoA) reductase inhibitors (statins) has a proven survival benefit in patients presenting with acute coronary syndromes (ACS). Patients presenting with ACS remain at significant risk of subsequent cardiovascular death and non-fatal myocardial infarction despite high compliance with current guideline indicated secondary prevention therapies. There remains, therefore, a need to… Expand
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Review on Rosuvastatin
TLDR
In vivo studies in animals, and in vitro studies in polite animal and human cells have shown rosuvastatin to possess a high uptake into, and property for, action within the liver, the organ for sterol lowering. Expand
Rosuvastatin protects against oxidized low-density lipoprotein-induced endothelial cell injury of atherosclerosis in vitro
TLDR
Findings indicated that rosuvastatin could protect HUVECs against ox-LDL-induced injury through its anti-oxidant effect and its ability to upregulate the expression of vascular endotheliocyte-protecting factors. Expand
Evaluation of drug interactions between fimasartan and rosuvastatin after single and multiple doses in healthy Caucasians
TLDR
Co-administration of fimasartan and rosuvastatin did not result in clinically relevant changes in the systemic exposure of fimsartan or rosuVastatin after single and multiple administrations, and they were well tolerated. Expand
Neuroprotective Effects of Rosuvastatin in Spinal Cord Ischemia-Reperfusion Injury in Rabbits
TLDR
Rosuvastatin may protect the spinal cord tissue against ischemic damage, by its anti-inflammation and antiapoptotic effect and may be a good candidate for clinical use during surgical procedures on the thoracoabdominal aorta. Expand
The relative bioavailability of 2 prototype fixed‐dose combination formulations for amlodipine and rosuvastatin in healthy white and Chinese subjects
TLDR
The FDC formulations demonstrated similar bioavailability to coadministered commercially available amlodipine and rosuvastatin and all treatments were generally well tolerated. Expand
Synthesis and characterization of Rosuvastatin calcium impurity A; a HMG-CoA reductase inhibitor
Abstract During the process development for multistep synthesis of Rosuvastatin calcium several impurities were obtained along with the final Rosuvastatin calcium. Out of this; synthesis of impurity… Expand
The Effect of Exosomes Derived from Bone Marrow Stem Cells in Combination with Rosuvastatin on Functional Recovery and Neuroprotection in Rats After Ischemic Stroke
TLDR
It seems that the use of exosomes and rosuvastatin, as a novel treatment regimen, might promote neurological recovery after the onset of stroke. Expand
FORMULATION AND CHARACTERIZATION OF ROSUVASTATIN CALCIUM NANOPARTICLES
Article history The aim of this study is to formulate and characterize Rosuvastatin loaded Chitosan nanoparticles prepared by ionic-gelation method. Rosuvastatin Calcium has a low bioavailability… Expand
Quantitative Analysis of Rosuvastatin Calcium in Bulkand Solid Pharmaceutical Dosage Forms Using Greenand Rapid Fourier-Transform Infrared SpectroscopicMethod
A fast, inexpensive and direct quantitative Fourier-Transform Infrared Spectroscopic method was established for rosuvastatin calcium for analysis in bulk and solid pharmaceutical dosage forms.… Expand
Highly sensitive ligand-binding assays in pre-clinical and clinical applications: immuno-PCR and other emerging techniques.
Recombinant DNA technology and corresponding innovations in molecular biology, chemistry and medicine have led to novel therapeutic biomacromolecules as lead candidates in the pharmaceutical drug… Expand
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