Rosuvastatin , Proprotein Convertase Subtilisin / Kexin Type 9 ( PCSK 9 ) Concentrations , and LDL Cholesterol Response : the JUPITER Trial

Abstract

METHODS: We measured plasma PCSK9 concentrations by ELISA at baseline and at 1 year in 500 men and 500 women participating in the Justification for Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial that randomly allocated participants to rosuvastatin 20 mg daily or placebo. We also evaluated rs11591147, a single… (More)

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