Rostral ventromedial medulla neurons that project to the spinal cord express multiple opioid receptor phenotypes.

@article{Marinelli2002RostralVM,
  title={Rostral ventromedial medulla neurons that project to the spinal cord express multiple opioid receptor phenotypes.},
  author={Silvia Marinelli and Christopher W Vaughan and Stephen A Schnell and Martin W Wessendorf and Macdonald J Christie},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 24},
  pages={
          10847-55
        }
}
The rostral ventromedial medulla (RVM) forms part of a descending pathway that modulates nociceptive neurotransmission at the level of the spinal cord dorsal horn. However, the involvement of descending RVM systems in opioid analgesia are a matter of some debate. In the present study, patch-clamp recordings of RVM neurons were made from rats that had received retrograde tracer injections into the spinal cord. More than 90% of identified spinally projecting RVM neurons responded to opioid… CONTINUE READING

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