Rostral optic tectum acquires caudal characteristics following ectopic Engrailed expression

  title={Rostral optic tectum acquires caudal characteristics following ectopic Engrailed expression},
  author={Cairine Logan and Andrea Wizenmann and Uwe Drescher and Bruno Monschau and Friedrich Bonhoeffer and Andrew G. S. Lumsden},
  journal={Current Biology},
BACKGROUND Expression of the homeobox-containing gene Engrailed (En) in an increasing rostral-to-caudal gradient in the dorsal mesencephalon is the earliest known marker for polarity of the chick optic tectum. In heterotopic transplantation experiments, En protein expression correlates well with the subsequent gradient of cytoarchitecture as well as the pattern of retinotectal projections. The En gradient also correlates with the expression of two putative retinal axon-guidance molecules, RAGS… CONTINUE READING


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