Rostral-caudal concentration gradients of histamine metabolites in human cerebrospinal fluid

@article{Prell2005RostralcaudalCG,
  title={Rostral-caudal concentration gradients of histamine metabolites in human cerebrospinal fluid},
  author={G. Prell and J. Khandelwal and P. Lewitt and J. Green},
  journal={Agents and Actions},
  year={2005},
  volume={26},
  pages={267-272}
}
The metabolites of histamine,tele-methylhistamine (t-MH) andtele-methylimidazoleacetic acid (t-MIAA), have a large concentration gradient between cisternal and lumbar CSF in the rhesus monkey. The possibility of a t-MH and/or t-MIAA gradient in man was studied in sequential samples of CSF withdrawn from the lumbar space from a healthy male. The mean levels of t-MH and t-MIAA in the 14–16 ml segment of CSF from 6 male volunteers was also measured.pros-Methylimidazoleacetic acid (p-MIAA), an… Expand

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