Rosin Nanoparticles as a Drug Delivery Carrier for the Controlled Release of Hydrocortisone

  title={Rosin Nanoparticles as a Drug Delivery Carrier for the Controlled Release of Hydrocortisone},
  author={Changmoon Lee and S. Lim and Gwang-Yun Kim and D. Kim and Joon Haeng Rhee and Ki-young Lee},
  journal={Biotechnology Letters},
  • Changmoon Lee, S. Lim, +3 authors Ki-young Lee
  • Published 2005
  • Chemistry, Medicine
  • Biotechnology Letters
  • Hydrocortisone (HC)-loaded rosin nanoparticles were prepared by a dispersion and dialysis method without addition of surfactant. They were spherical: 167–332 nm diam. The drug was loaded approximately 50% of initial feeding amount in all formulation. Release of hydrocortisone from the nanoparticles in vitro gradually decreased with increasing initial rosin content at pH 7.4. HC was also released very slowly at pH 1.2. Nanoparticles based on rosin thus are potentially useful as a drug delivery… CONTINUE READING
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