Rosiglitazone up-regulates lipoprotein lipase, hormone-sensitive lipase and uncoupling protein-1, and down-regulates insulin-induced fatty acid synthase gene expression in brown adipocytes of Wistar rats

@article{Teruel2005RosiglitazoneUL,
  title={Rosiglitazone up-regulates lipoprotein lipase, hormone-sensitive lipase and uncoupling protein-1, and down-regulates insulin-induced fatty acid synthase gene expression in brown adipocytes of Wistar rats},
  author={Teresa Teruel and Rosario Insa Hernandez and Eduardo Rial and Antonia Mart{\'i}n-Hidalgo and M. C{\'o}rdoba Lorenzo},
  journal={Diabetologia},
  year={2005},
  volume={48},
  pages={1180-1188}
}
Although thiazolidinediones are now widely used to treat type 2 diabetes, their mechanism of action remains largely unknown. They are agonists for the transcription factor PPARγ, and in addition to their insulin-sensitising effects, they can promote adipogenesis and control gene expression in adipose tissues. We have explored the effect of rosiglitazone on… CONTINUE READING