Rosiglitazone treatment reversed depression- but not psychosis-like behavior of db/db diabetic mice.


The objective of the present study was to examine the effect of long-term management of insulin resistance and hyperglycemia on neurobehavioral deficits in db/db mice. In this study, 5-week-old db/db and lean control mice were fed with rosiglitazone (20 mg/kg/day) mixed or standard chow for a duration of 5 weeks. Mice were monitored weekly for blood glucose… (More)
DOI: 10.1177/0269881111434620