Rosiglitazone stimulates nitric oxide synthesis in human aortic endothelial cells via AMP-activated protein kinase.

@article{Boyle2008RosiglitazoneSN,
  title={Rosiglitazone stimulates nitric oxide synthesis in human aortic endothelial cells via AMP-activated protein kinase.},
  author={James Graham Boyle and Pamela J. Logan and M A Ewart and James A. Reihill and Stuart A Ritchie and John M.C. Connell and Stephen J. Cleland and Ian P Salt},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 17},
  pages={11210-7}
}
The thiazolidinedione anti-diabetic drugs increase activation of endothelial nitric-oxide (NO) synthase by phosphorylation at Ser-1177 and increase NO bioavailability, yet the molecular mechanisms that underlie this remain poorly characterized. Several protein kinases, including AMP-activated protein kinase, have been demonstrated to phosphorylate endothelial NO synthase at Ser-1177. In the current study we determined the role of AMP-activated protein kinase in rosiglitazone-stimulated NO… CONTINUE READING

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