Rosiglitazone reversal of Tg2576 cognitive deficits is independent of peripheral gluco-regulatory status.

  title={Rosiglitazone reversal of Tg2576 cognitive deficits is independent of peripheral gluco-regulatory status.},
  author={Jennifer Rodriguez-Rivera and Larry A. Denner and Kelly Tennyson Dineley},
  journal={Behavioural brain research},
  volume={216 1},
Converging lines of evidence associate gluco-regulatory abnormalities and peroxisome-proliferator-activated receptor (PPAR) gamma function with increased risk for Alzheimer's disease (AD). In this study, we used the Tg2576 AD mouse model to test the hypothesis that cognitive improvement following 1 month of PPAR gamma agonism with rosiglitazone (RTZ) correlates with peripheral gluco-regulatory status. We assessed cognition and peripheral gluco-regulatory status of Tg2576 mice following 1 month… CONTINUE READING
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