Rosiglitazone reduces glucose-induced oxidative stress mediated by NAD(P)H oxidase via AMPK-dependent mechanism.

@article{Ceolotto2007RosiglitazoneRG,
  title={Rosiglitazone reduces glucose-induced oxidative stress mediated by NAD(P)H oxidase via AMPK-dependent mechanism.},
  author={Giulio Ceolotto and Alessandra Gallo and Italia Papparella and Lorenzo Franco and Ellen Murphy and Elisabetta Iori and Elisa Pagnin and Gian Paolo Fadini and Mattia Albiero and Andrea Semplicini and Angelo Avogaro},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2007},
  volume={27 12},
  pages={2627-33}
}
OBJECTIVE Hyperglycemia is the main determinant of long-term diabetic complications, mainly through induction of oxidative stress. NAD(P)H oxidase is a major source of glucose-induced oxidative stress. In this study, we tested the hypothesis that rosiglitazone (RSG) is able to quench oxidative stress initiated by high glucose through prevention of NAD(P)H oxidase activation. METHODS AND RESULTS Intracellular ROS were measured using the fluoroprobe TEMPO-9-AC in HUVECs exposed to control (5… CONTINUE READING
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Oxidative stress and electron spin resonance

  • M Kopàni, P Celec, L Danišovi, P Michalka, C. Biró
  • Clin Chim Acta
  • 2006
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