Rosiglitazone protects against cyclosporine-induced pancreatic and renal injury in rats.

@article{Chung2005RosiglitazonePA,
  title={Rosiglitazone protects against cyclosporine-induced pancreatic and renal injury in rats.},
  author={Byung Ha Chung and Can Li and Bo kyung Sun and Sun Woo Lim and Kyung Ohk Ahn and Ji Hun Yang and Yoon Hee Choi and Kun Ho Yoon and Akira Sugawara and Sadayoshi Ito and Jin Oak Kim and Chul Woo Yang},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2005},
  volume={5 8},
  pages={1856-67}
}
Rosiglitazone (RGTZ) has protective effect against various types of injury. This study was performed to evaluate the effect of RGTZ on pancreatic and renal injury caused by cyclosporine (CsA). CsA (15 mg/kg) and RGTZ (3 mg/kg) were administered alone and together to the rats for 28 days. The effect of RGTZ on CsA-induced pancreatic injury was evaluated by intraperitoneal glucose tolerance test (IPGTT), plasma insulin concentrations and pancreatic beta-cell morphology. The effect of RGTZ on CsA… CONTINUE READING
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