Rosiglitazone and retinoic acid inhibit proliferation and induce apoptosis in the HCT-15 human colorectal cancer cell line.

@article{Miao2011RosiglitazoneAR,
  title={Rosiglitazone and retinoic acid inhibit proliferation and induce apoptosis in the HCT-15 human colorectal cancer cell line.},
  author={Ruizheng Miao and Tao Xu and Liqing Liu and Meng Wang and Yanming Jiang and Jianfeng Li and Renle Guo},
  journal={Experimental and therapeutic medicine},
  year={2011},
  volume={2 3},
  pages={413-417}
}
The aim of this study was to explore the effects of rosiglitazone (RSG) in combination with all-trans retinoic acid (ATRA) on the proliferation and apoptosis of the HCT-15 human colorectal cancer cell line. HCT-15 cells were divided into a blank control group, a vehicle control group and experimental groups (RSG only or ATRA only or RSG plus ATRA). Growth inhibition was examined using the MTT assay. Apoptosis and cell cycle progression were examined by flow cytometry. The expression of COX-2… CONTINUE READING
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