Rosiglitazone Rescues Memory Impairment in Alzheimer's Transgenic Mice: Mechanisms Involving a Reduced Amyloid and Tau Pathology

@article{Escribano2010RosiglitazoneRM,
  title={Rosiglitazone Rescues Memory Impairment in Alzheimer's Transgenic Mice: Mechanisms Involving a Reduced Amyloid and Tau Pathology},
  author={Luis Lara Escribano and Ana-maria Simon and Esther Gimeno and Mar Cuadrado-Tejedor and Rakel L{\'o}pez de Maturana and Ana Garc{\'i}a-Osta and Ana Ricobaraza and Alberto P{\'e}rez-Mediavilla and Joaqu{\'i}n del R{\'i}o and Diana Frechilla},
  journal={Neuropsychopharmacology},
  year={2010},
  volume={35},
  pages={1593-1604}
}
Clinical studies suggest that agonists at peroxisome proliferator-activated receptor gamma (PPARγ) may exert beneficial effects in patients with mild-to-moderate Alzheimer's disease (AD), but the mechanism for the potential therapeutic interest of this class of drugs has not yet been elucidated. Here, in mice overexpressing mutant human amyloid precursor protein, we found that chronic treatment with rosiglitazone, a high-affinity agonist at PPARγ, facilitated β-amyloid peptide (Aβ) clearance… CONTINUE READING

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