RosettaDock in CAPRI rounds 6–12

@article{Wang2007RosettaDockIC,
  title={RosettaDock in CAPRI rounds 6–12},
  author={Chu Wang and Ora Schueler‐Furman and Ingemar Andr{\'e} and Nir London and Sarel Jacob Fleishman and Philip Bradley and Bin Qian and David Baker},
  journal={Proteins: Structure},
  year={2007},
  volume={69}
}
A challenge in protein–protein docking is to account for the conformational changes in the monomers that occur upon binding. The RosettaDock method, which incorporates sidechain flexibility but keeps the backbone fixed, was found in previous CAPRI rounds (4 and 5) to generate docking models with atomic accuracy, provided that conformational changes were mainly restricted to protein sidechains. In the recent rounds of CAPRI (6–12), large backbone conformational changes occur upon binding for… Expand
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