Rosetta predictions in CASP5: successes, failures, and prospects for complete automation.

@article{Bradley2003RosettaPI,
  title={Rosetta predictions in CASP5: successes, failures, and prospects for complete automation.},
  author={Philip Bradley and Dylan Chivian and Jens Meiler and Kira M. S. Misura and Carol A. Rohl and William R. Schief and William J. Wedemeyer and Ora Schueler-Furman and Paul Murphy and Jack Schonbrun and Charles E M Strauss and David Baker},
  journal={Proteins},
  year={2003},
  volume={53 Suppl 6},
  pages={457-68}
}
We describe predictions of the structures of CASP5 targets using Rosetta. The Rosetta fragment insertion protocol was used to generate models for entire target domains without detectable sequence similarity to a protein of known structure and to build long loop insertions (and N-and C-terminal extensions) in cases where a structural template was available. Encouraging results were obtained both for the de novo predictions and for the long loop insertions; we describe here the successes as well… CONTINUE READING
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