Roseotoxin B Improves Allergic Contact Dermatitis through a Unique Anti-Inflammatory Mechanism Involving Excessive Activation of Autophagy in Activated T Lymphocytes.

@article{Wang2016RoseotoxinBI,
  title={Roseotoxin B Improves Allergic Contact Dermatitis through a Unique Anti-Inflammatory Mechanism Involving Excessive Activation of Autophagy in Activated T Lymphocytes.},
  author={Xing Qi Wang and Chunhui Hu and Xingxin Wu and Shiyu Wang and A. Zhang and Wei Chen and Yan Shen and Renxiang Tan and Xuefeng Wu and Yang Sun and Qiang Xu},
  journal={The Journal of investigative dermatology},
  year={2016},
  volume={136 8},
  pages={
          1636-1646
        }
}
An immunosuppressant agent with negligible or acceptable toxicity may provide a better therapeutic strategy for treatment of allergic contact dermatitis. We identified a natural cyclopeptide, roseotoxin B, that effectively suppressed cell proliferation and the production of proinflammatory cytokines in activated T cells but exhibited little naive T-cell toxicity at concentrations of 0.3-1 μmol/L. In addition, roseotoxin B inhibited the activation of AKT and signal transducer and activator of… 
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