Roscovitine: a novel regulator of P/Q-type calcium channels and transmitter release in central neurons.

@article{Yan2002RoscovitineAN,
  title={Roscovitine: a novel regulator of P/Q-type calcium channels and transmitter release in central neurons.},
  author={Zhen Yan and Ping Chi and James A. Bibb and Timothy A Ryan and Paul Greengard},
  journal={The Journal of physiology},
  year={2002},
  volume={540 Pt 3},
  pages={761-70}
}
Roscovitine is widely used for inhibition of cdk5, a cyclin-dependent kinase expressed predominantly in the brain. A novel function of roscovitine, i.e. an effect on Ca(2+) channels and transmitter release in central neurons, was studied by whole-cell voltage-clamp recordings and time-lapse fluorescence imaging techniques. Extracellular application of roscovitine markedly enhanced the tail calcium current following repolarization from depolarized voltages. This effect was rapid, reversible and… CONTINUE READING