Rosa26-GFP Direct Repeat (RaDR-GFP) Mice Reveal Tissue- and Age-Dependence of Homologous Recombination in Mammals In Vivo

@inproceedings{SukupJackson2014Rosa26GFPDR,
  title={Rosa26-GFP Direct Repeat (RaDR-GFP) Mice Reveal Tissue- and Age-Dependence of Homologous Recombination in Mammals In Vivo
},
  author={Michelle R. Sukup-Jackson and Orsolya Kiraly and Jennifer E Kay and Li Na and Elizabeth A. Rowland and Kelly E. Winther and Danielle N. Chow and Takafumi Kimoto and Tetsuya Matsuguchi and Vidya S. Jonnalagadda and Vilena I. Maklakova and Vijay Raj Singh and Dushan N. Wadduwage and Jagath C. Rajapakse and Peter T. C. So and Lara S. Collier and Bevin P. Engelward},
  booktitle={PLoS genetics},
  year={2014}
}
Homologous recombination (HR) is critical for the repair of double strand breaks and broken replication forks. Although HR is mostly error free, inherent or environmental conditions that either suppress or induce HR cause genomic instability. Despite its importance in carcinogenesis, due to limitations in our ability to detect HR in vivo, little is known about HR in mammalian tissues. Here, we describe a mouse model in which a direct repeat HR substrate is targeted to the ubiquitously expressed… CONTINUE READING
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