Ror family receptor tyrosine kinases regulate the maintenance of neural progenitor cells in the developing neocortex.

@article{Endo2012RorFR,
  title={Ror family receptor tyrosine kinases regulate the maintenance of neural progenitor cells in the developing neocortex.},
  author={Mitsuharu Endo and Ryosuke Doi and Michiru Nishita and Yasuhiro Minami},
  journal={Journal of cell science},
  year={2012},
  volume={125 Pt 8},
  pages={
          2017-29
        }
}
The Ror family receptor tyrosine kinases (RTKs), Ror1 and Ror2, have been shown to play crucial roles in developmental morphogenesis by acting as receptors or co-receptors to mediate Wnt5a-induced signaling. Although Ror1, Ror2 and Wnt5a are expressed in the developing brain, little is known about their roles in the neural development. Here we show that Ror1, Ror2 and their ligand Wnt5a are highly expressed in neocortical neural progenitor cells (NPCs). Small interfering RNA (siRNA)-mediated… CONTINUE READING

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