Rorα, a pivotal nuclear receptor for Purkinje neuron survival and differentiation: From development to ageing

@article{Boukhtouche2006RorAP,
  title={Rorα, a pivotal nuclear receptor for Purkinje neuron survival and differentiation: From development to ageing},
  author={Fatiha Boukhtouche and Mohamed Doulazmi and Florence Fr{\'e}d{\'e}ric and Isabelle Dusart and Bernard Brugg and Jean Mariani},
  journal={The Cerebellum},
  year={2006},
  volume={5},
  pages={97-104}
}
RORα (Retinoid-relatedOrphanReceptor) is a transcription factor belonging to the superfamily of nuclear receptors. The spontaneousstaggerer (sg) mutation, which consists of a deletion in theRora gene, has been shown to cause the loss of function of the RORα protein. The total loss of RORα expression leads to cerebellar developmental defects, particularly to a dramatic decreased survival of Purkinje cells and an early block in the differentiation process. This review focuses on recent studies… CONTINUE READING

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