Ropivacaine impairs mitochondrial biogenesis by reducing PGC-1α.

@article{Niu2018RopivacaineIM,
  title={Ropivacaine impairs mitochondrial biogenesis by reducing PGC-1$\alpha$.},
  author={Zejun Niu and Jiaming Tang and Yueyi Ren and Wei Feng},
  journal={Biochemical and biophysical research communications},
  year={2018},
  volume={504 2},
  pages={
          513-518
        }
}
Ropivacaine is one of the commonly used local anesthetics in medical and dental care. However, preclinical and observational studies indicate that ropivacaine could have substantial side effects including neurotoxicity, which has raised concern regarding the safety of this drug. In the present study, we investigated the effects of clinically relevant doses of ropivacaine on mitochondrial biogenesis and function in neuronal cells. Our data indicate that exposure to ropivacaine leads to reduced… Expand
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Brain-Derived Neurotrophic Factor Alleviates Ropivacaine-Induced Neuronal Damage by Enhancing the Akt Signaling Pathway
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BDNF can alleviate ropivacaine-induced neuronal injury by activating Akt signaling pathway, consequently modulating the proliferation and apoptosis of neurons. Expand
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Is Mitochondria Biogenesis and Neuronal Loss Prevention in Rat Hippocampus Promoted by Apigenin?
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