Rop, a drosophila homolog of yeast Sec1 and vertebrate n-Sect/Munc-18 proteins, is a negative regulator of neurotransmitter release in vivo

@article{Schulze1994RopAD,
  title={Rop, a drosophila homolog of yeast Sec1 and vertebrate n-Sect/Munc-18 proteins, is a negative regulator of neurotransmitter release in vivo},
  author={Karen L Schulze and J. Troy Littleton and Adi Salzberg and Naomi Halachmi and Hugo J. Bellen},
  journal={Neuron},
  year={1994},
  volume={13},
  pages={1099-1108}
}
The mammalian homolog of the yeast Sec1p, n-Sec1/Munc-18 has been demonstrated to bind the presynaptic membrane protein syntaxin, a putative synaptic vesicle docking protein. To determine the role of n-Sec1/Munc-18 in neurotransmitter release in vivo, we have overexpressed the Drosophila homolog, rop, in third instar larvae and measured the electrophysiological consequences at the neuromuscular junction. A 3- to 5-fold induction of the rop protein causes a dramatic decrease in neurotransmitter… CONTINUE READING

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