Root Effect Hemoglobin May Have Evolved to Enhance General Tissue Oxygen Delivery

@article{Rummer2013RootEH,
  title={Root Effect Hemoglobin May Have Evolved to Enhance General Tissue Oxygen Delivery},
  author={J. Rummer and D. McKenzie and A. Innocenti and C. Supuran and C. Brauner},
  journal={Science},
  year={2013},
  volume={340},
  pages={1327 - 1329}
}
Holding Your Breath Hemoglobin and myoglobin are widely responsible for oxygen transport and storage (see the Perspective by Rezende). The ability of diving mammals to obtain enough oxygen to support extended dives and foraging is largely dependent on muscle myoglobin (Mb) content. Mirceta et al. (p. 1303) found that in mammalian lineages with an aquatic or semiaquatic lifestyle, Mb net charge increases, which may represent an adaptation to inhibit self-association of Mb at high intracellular… Expand
Root Effect Haemoglobins in Fish May Greatly Enhance General Oxygen Delivery Relative to Other Vertebrates
TLDR
These characteristics may be central to performance of athletic fish species such as salmonids, but may indicate that general tissue oxygen delivery may have been the incipient function of Root effect Hbs in fish, a trait strongly associated with the adaptive radiation of teleosts. Expand
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TLDR
Although data are limited, these attributes may be general characteristics of teleosts and the generation and elimination of pH disequilibrium states at the RBC will likely enhance Hb-O2 unloading to some degree in other vertebrates. Expand
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The present study determined that in rainbow trout this system may be functional even at low concentrations of circulating catecholamines, and with β-NHE short-circuiting, Atlantic and coho salmon may be able to increase Hb–O2 unloading by up to 74 and 159%, respectively, as determined by modeling based on O2 equilibrium curves. Expand
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Biochemical and metabolic evidence supports a role for red blood cell carbonic anhydrase activity in dictating the rate of O2 delivery in red drum (Sciaenops ocellatus). Expand
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TLDR
How myoglobin and hemoglobin, respiratory pigments responsible for oxygen uptake, transport, and storage have evolved in vertebrates to meet the demands of different lifestyles is discussed. Expand
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TLDR
It is suggested that this unique mode of tissue O2 transfer evolved in the Triassic/Jurassic Period, when O2 levels were low, ultimately giving rise to the most extensive adaptive radiation of extant vertebrates, the teleost fishes. Expand
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TLDR
Results show that maximal exercise performance in salmon, and thus a successful spawning migration, may not be possible without paCA, and the recruitment of paCA was plastic and increased following hypoxic acclimation. Expand
High affinity and temperature sensitivity of blood oxygen binding in Pangasianodon hypophthalmus due to lack of chloride-hemoglobin allosteric interaction.
TLDR
It is demonstrated how a potent mechanism for increasing O2 affinity is linked to increased temperature sensitivity of O2 transport and provides a basic framework for a better understanding of how hypoxia-adapted species will react to increasing temperatures. Expand
The O2 and CO2 Transport System in Teleosts and the Specialized Mechanisms That Enhance Hb–O2 Unloading to Tissues
TLDR
A novel mechanism of enhanced Hb–O2 unloading in teleosts is described and discussed, one that relies on the heterogeneous distribution of plasma-accessible carbonic anhydrase (PACA), an intrinsic characteristic of the cardiovascular system, and a vastly understudied area not only in fishes. Expand
Teleost red blood cells actively enhance the passive diffusion of oxygen that was discovered by August Krogh.
  • T. Harter, C. Brauner
  • Medicine, Chemistry
  • Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
  • 2020
TLDR
Teleost fishes have evolved a mechanism by which adrenergic sodium-proton-exchangers on the red blood cell membrane actively create H+ gradients that are short-circuited in the presence of plasma-accessible carbonic anhydrase at the tissue capillaries, which allows teleosts to unload more O2 at their tissues without compromising O2 diffusion gradients and therefore, to use the available O2 carrying capacity of the blood to a greater degree. Expand
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References

SHOWING 1-10 OF 128 REFERENCES
Plasma-accessible carbonic anhydrase at the tissue of a teleost fish may greatly enhance oxygen delivery: in vitro evidence in rainbow trout, Oncorhynchus mykiss
TLDR
If plasma-accessible CA-mediated short-circuiting is operational in vivo, the combined Bohr-Root effect system unique to teleost fishes could markedly enhance tissue O2 delivery far in excess of that in vertebrates possessing a Bohr effect alone and may lead to insights about the early evolution of the Root effect. Expand
Increased hemoglobin-oxygen affinity does not decrease skeletal muscle oxygen consumption.
  • B. Ross, M. Hlastala
  • Chemistry, Medicine
  • Journal of applied physiology: respiratory, environmental and exercise physiology
  • 1981
TLDR
The data suggest that the position of the oxygen dissociation curve may not be as important as originally thought in determining skeletal muscle oxygen delivery, as compared with normal blood over a wide range of saturations. Expand
Historical reconstructions of evolving physiological complexity: O2 secretion in the eye and swimbladder of fishes
  • M. Berenbrink
  • Biology, Medicine
  • Journal of Experimental Biology
  • 2007
TLDR
It is shown that oxygen secretion first evolved in the eyes of fishes, presumably for improved oxygen supply to an avascular, metabolically active retina, and the increasing availability of molecular phylogenetic trees for evolutionary reconstructions may be as important for understanding physiological diversity in the postgenomic era as the increase of genomic sequence information in single model species. Expand
CARBONIC ANHYDRASE INJECTION PROVIDES EVIDENCE FOR THE ROLE OF BLOOD ACID-BASE STATUS IN STIMULATING VENTILATION AFTER EXHAUSTIVE EXERCISE IN RAINBOW TROUT
  • Wood, Munger
  • Chemistry, Medicine
  • The Journal of experimental biology
  • 1994
TLDR
There was a strong correlation between increases in relative ventilation and decreases in pHa after exhaustive exercise, and other recent studies indicating an important secondary drive to ventilation in fish based on arterial acid­base status, in addition to the primary drive based onarterial O2 levels. Expand
Enhanced oxygenation in vivo by allosteric inhibitors of hemoglobin saturation.
The in vivo effects on hemoglobin (Hb)-O2 affinity and tissue PO2 were investigated after intraperitoneal administration of 2-[4-(((dichloroanilino)-carbonyl)methyl)phenoxyl]-2-methyl propionic acidExpand
Tissue oxygen extraction during hypovolemia: role of hemoglobin P50.
TLDR
It is concluded that diffusion limitation does not initiate the early fall in VO2 below the critical QO2 and an alternative model to explain the onset of supply dependency is offered. Expand
The distribution and physiological significance of carbonic anhydrase in vertebrate gas exchange organs.
The enzyme carbonic anhydrase (CA) catalyzes the reversible hydration/dehydration of CO(2) and water, maintaining a near-instantaneous equilibrium among all chemical species involved in the reaction.Expand
Carbonic anhydrase and acid–base regulation in fish
TLDR
In this review, the CA isoforms that have been identified to date in fish will be discussed together with their tissue localizations and roles in systemic acid–base regulation. Expand
Metabolic changes associated with acid-base regulation during hypercarbia in the CO2-tolerant chondrostean, white sturgeon (Acipenser transmontanus).
  • D. Baker, C. Brauner
  • Biology, Medicine
  • Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
  • 2012
TLDR
Empirical support is provided for the hypothesis that preferential pHi regulation is not metabolically costly, and thus may have been a strategy strongly selected for in fishes encountering short-term hypercarbia. Expand
The role of catecholamines in erythrocyte pH regulation and oxygen transport in rainbow trout (Salmo gairdneri) during exercise.
TLDR
Catecholamines play an important role in maintaining oxygen transport to aerobic muscles, following burst swimming and the associated acidotic conditions, and are concluded to be responsible for the increase in erythrocytic pH. Expand
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