Room for Improvement in Conducting and Reporting Non-Inferiority Randomized Controlled Trials on Drugs: A Systematic Review

@inproceedings{Wangge2010RoomFI,
  title={Room for Improvement in Conducting and Reporting Non-Inferiority Randomized Controlled Trials on Drugs: A Systematic Review},
  author={Grace Wangge and Olaf H Klungel and Kit C. B. Roes and Anthonius de Boer and Arno Wilhelmus Hoes and Mirjam J. Knol},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND A non-inferiority (NI) trial is intended to show that the effect of a new treatment is not worse than the comparator. We conducted a review to identify how NI trials were conducted and reported, and whether the standard requirements from the guidelines were followed. METHODOLOGY AND PRINCIPAL FINDINGS From 300 randomly selected articles on NI trials registered in PubMed at 5 February 2009, we included 227 NI articles that referred to 232 trials. We excluded studies on… CONTINUE READING

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