Romidepsin for cutaneous T-cell lymphoma.

  title={Romidepsin for cutaneous T-cell lymphoma.},
  author={H Miles Prince and Michael R. Dickinson},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={18 13},
Cutaneous T-cell lymphomas (CTCL) are relatively rare lymphomas with an annual incidence of approximately 0.2 to 0.8/100,000 and comprise a variety of clinical entities; mycosis fungoides or its leukemic variant Sezary syndrome account for the majority of cases. Advanced-stage disease is typically treated with bexarotene (a retinoid), interferon, or conventional chemotherapeutic agents, but relapses are inevitable. Histone deacetylase inhibitors, which modify the epigenome, are an attractive… CONTINUE READING

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