Romidepsin Overcomes Cell Adhesion-Mediated Drug Resistance in Multiple Myeloma Cells

  title={Romidepsin Overcomes Cell Adhesion-Mediated Drug Resistance in Multiple Myeloma Cells},
  author={Piyanuch Sripayap and Tadashi Nagai and Kaoru Hatano and Jiro Kikuchi and Yusuke Furukawa and Keiya Ozawa},
  journal={Acta Haematologica},
  pages={1 - 4}
5] . These effects might ultimately affect the expression and function of various intracellular molecules, including transcription factors. We therefore hypothesized that these agents influence the expression levels of adhesion molecules in MM cells. To verify this hypothesis, we examined the effect of the HDI romidepsin and DNAmethylating agent azacitidine on the expression levels of CD49d and two other representative adhesion molecules, CD29 and CD138, by flow cytometry analyses in two human… 

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