Rolling of Human Bone-Metastatic Prostate Tumor Cells on Human Bone Marrow Endothelium under Shear Flow Is Mediated by E-Selectin

@article{Dimitroff2004RollingOH,
  title={Rolling of Human Bone-Metastatic Prostate Tumor Cells on Human Bone Marrow Endothelium under Shear Flow Is Mediated by E-Selectin},
  author={Charles J. Dimitroff and Mirna Lechpammer and Denise Long-Woodward and Jeffery L. Kutok},
  journal={Cancer Research},
  year={2004},
  volume={64},
  pages={5261 - 5269}
}
Prostate tumor cells preferentially adhere to bone marrow endothelial cells (BMECs) compared with endothelial linings from other tissue microvessels, implicating the importance of BMEC adhesion in the predilection of prostate tumor metastasis to bone. E (endothelial)-selectin, which functions as an initiator of leukocyte adhesion to target tissue endothelium, is constitutively expressed on BMECs, suggesting that prostate tumor cells could use this adhesive mechanism to initiate their migration… 
Tumor and Stem Cell Biology De fi nition of Molecular Determinants of Prostate Cancer Cell Bone Extravasation
Advanced prostate cancer commonly metastasizes to bone, but transit of malignant cells across the bone marrow endothelium (BMEC) remains a poorly understood step in metastasis. Prostate cancer cells
Definition of molecular determinants of prostate cancer cell bone extravasation.
TLDR
How metastatic prostate cancer cells breach BMEC monolayers in a step-wise fashion under physiologic hemodynamic flow is described and the requirement for E-selectin ligands, α1,3 fucosyltransferases, β1 and αVβ3 integrins, and Rac/Rap1 GTPases in mediating prostate cancer cell homing and entry into bone is unified.
Identification of leukocyte E-selectin ligands, P-selectin glycoprotein ligand-1 and E-selectin ligand-1, on human metastatic prostate tumor cells.
TLDR
Findings implicate a functional role of PSGL-1 in the bone tropism of prostate tumor cells and establish a new perspective into the molecular mechanism of human prostate tumor metastasis.
Circulating Tumor Cells from Prostate Cancer Patients Interact with E-Selectin under Physiologic Blood Flow
TLDR
CTC-Endothelial interactions provide a novel insight into potential adhesive mechanisms of prostate CTCs as a means to initiate metastasis.
E-selectin ligand-1 controls circulating prostate cancer cell rolling/adhesion and metastasis
TLDR
It is shown that knocking down of E-selectin ligand 1(ESL-1), significantly impaired PCa cells' rolling capacity and reduced cancer aggressiveness contributes to PCa metastasis, and that is in part controlled by ESL-1.
Cadherin-11-mediated interactions with bone marrow stromal/osteoblastic cells support selective colonization of breast cancer cells in bone.
TLDR
The results suggest that cadherin-11 promotes homing and migration to bone and osteoclastogenesis through mediating the homophilic interactions of breast cancer cells with marrow stromal/osteoblastic cells, thereby enhancing bone metastases.
Human fucosyltransferase 6 enables prostate cancer metastasis to bone
TLDR
Comparison of FT3, FT6 and FT7 gene expression in existing clinical samples showed significant upregulation of FT6 in PCa-distant metastases, suggesting that FT6 is a key mediator of PCa cells trafficking to the BM and may serve as a viable drug target in preclinical tests of therapeutics for reduction of PCA bone metastasis.
The interaction between CD44 on tumour cells and hyaluronan under physiologic flow conditions: implications for metastasis formation
TLDR
Certain tumour entities bind to HA under physiological shear stresses so that HA can be considered a further ligand for cell extravasation in haematogenous metastasis.
Gangliosides expressed on breast cancer cells are E-selectin ligands.
TLDR
The results demonstrate that breast cancer cells express sialylated glycosphingolipids (gangliosides) as E-selectin ligands that may be targeted for prevention of metastasis.
Analysis of glycosyltransferase expression in metastatic prostate cancer cells capable of rolling activity on microvascular endothelial (E)-selectin.
TLDR
The results implicate the importance of alpha1,3 FT3, FT6, and/or FT7 in sLe(X) and ESL synthesis on metastatic PCa cells and contrast the expression level of glycosyltransferases in ESL(+) MDA cells among other ESL(-) metastaticPCa cell lines.
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