Rolling circle replication of DNA in yeast mitochondria.

  title={Rolling circle replication of DNA in yeast mitochondria.},
  author={Ryszard Maleszka and Paul Skelly and George Desmond Clark-Walker},
  journal={The EMBO journal},
  volume={10 12},
The conformation of mitochondrial DNA (mtDNA) from yeasts has been examined by pulsed field gel electrophoresis and electron microscopy. The majority of mtDNA from Candida (Torulopsis) glabrata (mtDNA unit size, 19 kb) exists as linear molecules ranging in size from 50 to 150 kb or 2-7 genome units. A small proportion of mtDNA is present as supercoiled or relaxed circular molecules. Additional components, detected by electron microscopy, are circular molecules with either single- or double… CONTINUE READING